STUDIES ON ALTERATIONS OF SERUM PROTEINS, LIPID PROFILE AND BILIRUBIN LEVELS IN PREECLAMPTIC WOMEN
ABSTRACT
This study was carried out to determine the levels of proteins, bilirubin and lipid profile of pre-eclamptic patients attending Imo state specialist hospital, Umuguma. Sixty(60) subjects aged 25-40 years were recruited for the study and they were divided into two groups of thirty(30) pre-eclamptic women and thirty(30) apparently healthy pregnant women. The sample was collected using a standard clean venipuncture technique and the statistical analysis was carried out using statistical package for social sciences(SPSS). The result obtained showed a significant decrease in total protein and albumin in pre-eclampsia women with mean values of 60.02±3.07g/l and 30.67±3.3g/l when compared with apparently healthy pregnant women with mean values of 65.69±4.9g/l and 36.30±2.9g/l at P<0.05. In the bilirubin, both Total Bilirubin and Conjugated Bilirubin showed a significant increase in pre-eclamptic women with mean values of 0.7±0.15mg/dl and 0.22±0.097mg/dl when compared with the apparently healthy pregnant women with mean values 0.57±0.20mg/dl and 0.10±0.04mg/dl at P<0.05. For lipid profile, Total Cholesterol(Tc), Triglyceride(Tg) and Low Density Lipoprotein(LDL) showed a significant increase in Pre-eclamptic women with mean values of 231.34±18.59mg/dl, 162.32±25.40mg/dl and 176.65±27.26mg/dl when compared with the apparently healthy pregnant women with mean values of 201.79±16.63mg/dl, 84.47±8.69mg/dl and 54.18±4.49 mg/dl at P<0.05 while High Density Lipoprotein(HDL) shows a significant decrease in pre-eclamptic women with mean values of 44.27±4.11mg/dl when compared with the apparently healthy pregnant women with mean values of 49.50±7.25mg/dl at P<0.05.This findings shows that pre-eclampsia is associated with hypoproteinaemia, hypoalbuminaemia, hyperbilirubinaemia and hyperlipidaemia Hence could probably serve as a biochemical marker in pre-eclampsia.
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